# Multiscale Entropies¶

## Functions for estimating the multiscale entropy of a univariate time series.¶

Multiscale entropy can be calculated using any of the Base Entropies: `ApEn`, `AttnEn`, `BubbEn`, `CondEn`, `CoSiEn`, `DistEn`, `DispEn`, `EnofEn`, `FuzzEn`, `GridEn`, `IncrEn`, `K2En`, `PermEn`, `PhasEn`, `SampEn`, `SlopEn`, `SpecEn`, `SyDyEn`.

Important

Multiscale cross-entropy functions have two positional arguments:

1. the time series signal, `Sig` (a vector > 10 elements),

2. the multiscale entropy object, `Mobj`.

`MSobject`(EnType, varargin)

MSobject creates an object to store multiscale entropy parameters.

[Mobj] = MSobject()

Returns a multiscale entropy object (`Mobj`) based on that orignially proposed by Costa et al. (2002) using the following default parameters: EnType = `'SampEn'`, embedding dimension = 2, time delay = 1, radius = 0.2*SD(`Sig`), logarithm = natural

[Mobj] = MSobject(EnType)

Returns a multiscale entropy object using the specified entropy method (`EnType`) and the default parameters for that entropy method. To see the default parameters for a particular entropy method, type: help EnType (e.g. `help SampEn`)

[Mobj] = MSobject(EnType, name, value, …)

Returns a multiscale entropy object using the specified entropy method (`EnType`) and the name/value parameters for that particular method. To see the default parameters for a particular entropy method, type: help EnType (e.g. `help SampEn`)

`EnType` can be any of the following (case sensitive) entropies:

• `'ApEn'` - Approximate Entropy

• `'SampEn'` - Sample Entropy

• `'FuzzEn'` - Fuzzy Entropy

• `'K2En'` - Kolmogorov Entropy

• `'PermEn'` - Permutation Entropy

• `'CondEn'` - Conditional Entropy

• `'DistEn'` - Distribution Entropy

• `'DispEn'` - Dispersion Entropy

• `'SpecEn'` - Spectral Entropy

• `'SyDyEn'` - Symbolic Dynamic Entropy

• `'IncrEn'` - Increment Entropy

• `'CoSiEn'` - Cosine Similarity Entropy

• `'PhasEn'` - Phase Entropy

• `'SlopEn'` - Slope Entropy

• `'BubbEn'` - Bubble Entropy

• `'GridEn'` - Grid Distribution Entropy

• `'EnofEn'` - Entropy of Entropy

• `'AttnEn'` - Attention Entropy

• `'XApEn'` - Cross-Approximate Entropy

• `'XSampEn'` - Cross-Sample Entropy

• `'XFuzzEn'` - Cross-Fuzzy Entropy

• `'XK2En'` - Cross-Kolmogorov Entropy

• `'XPermEn'` - Cross-Permutation Entropy

• `'XCondEn'` - Cross-Conditional Entropy

• `'XDistEn'` - Cross-Distribution Entropy

• `'XSpecEn'` - Cross-Spectral Entropy

• `'SampEn2D'` - Bidimensional Sample Entropy

• `'FuzzEn2D'` - Bidimensional Fuzzy Entropy

• `'DispEn2D'` - Bidimensional Dispersion Entropy

• `'DistEn2D'` - Bidimensional Distribution Entropy

• `'EspEn2D'` - Bidimensional Espinosa Entropy

• `'PermEn2D'` - Bidimensional Permutation Entropy

MSEn, XMSEn, MSEn2D, cMSEn, rMSEn, hMSEn,rXMSEn, cXMSEn, hXMSEn

The following functions use the multiscale entropy object shown above.

`MSEn`(Sig, Mobj, varargin)

MSEn returns the multiscale entropy of a univariate data sequence.

[MSx,CI] = MSEn(Sig, Mobj)

Returns a vector of multiscale entropy values (`MSx`) and the complexity index (`CI`) of the data sequence `Sig` using the parameters specified by the multiscale object (`Mobj`) over 3 temporal scales with coarse- graining (default).

[MSx,CI] = MSEn(Sig, Mobj, name, value, …)

Returns a vector of multiscale entropy values (`MSx`) and the complexity index (`CI`) of the data sequence `Sig` using the parameters specified by the multiscale object (`Mobj`) and the following name/value pair arguments:

• `Scales` - Number of temporal scales, an integer > 1 (default = 3)

• `Methodx` - Graining method, one of the following: [default = `'coarse'`] {`'coarse'`, `'modified'`, `'imf'`, `'timeshift'`}

• `RadNew` - Radius rescaling method, an integer in the range [1 4]. When the entropy specified by `Mobj` is `SampEn` or `ApEn`, RadNew rescales the radius threshold in each sub-sequence at each time scale (Xt). If a radius value (`r`) is specified by `Mobj`, this becomes the rescaling coefficient, otherwise it is set to 0.2 (default). The value of `RadNew` specifies one of the following methods:

•  Standard Deviation - r*std(Xt)

•  Variance - r*var(Xt)

•  Mean Absolute Deviation - r*mad(Xt)

•  Median Absolute Deviation - r*mad(Xt,1)

• `Plotx` - When `Plotx == true`, returns a plot of the entropy value at each time scale (i.e. the multiscale entropy curve) [default: false]

For further information on multiscale graining procedures, see the EntropyHub guide

MSobject, rMSEn, cMSEn, hMSEn, XMSEn, cXMSEn, hXMSEn, SampEn

References:
 Madalena Costa, Ary Goldberger, and C-K. Peng,

“Multiscale entropy analysis of complex physiologic time series.” Physical review letters 89.6 (2002): 068102.

 Vadim V. Nikulin, and Tom Brismar,

“Comment on “Multiscale entropy analysis of complex physiologic time series”.” Physical Review Letters 92.8 (2004): 089803.

 Madalena Costa, Ary L. Goldberger, and C-K. Peng.

“Costa, Goldberger, and Peng reply.” Physical Review Letters 92.8 (2004): 089804.

 Madalena Costa, Ary L. Goldberger and C-K. Peng,

“Multiscale entropy analysis of biological signals.” Physical review E 71.2 (2005): 021906.

 Ranjit A. Thuraisingham and Georg A. Gottwald,

“On multiscale entropy analysis for physiological data.” Physica A: Statistical Mechanics and its Applications 366 (2006): 323-332.

 Meng Hu and Hualou Liang,

“Intrinsic mode entropy based on multivariate empirical mode decomposition and its application to neural data analysis.” Cognitive neurodynamics 5.3 (2011): 277-284.

 Anne Humeau-Heurtier

“The multiscale entropy algorithm and its variants: A review.” Entropy 17.5 (2015): 3110-3123.

 Jianbo Gao, et al.,

“Multiscale entropy analysis of biological signals: a fundamental bi-scaling law.” Frontiers in computational neuroscience 9 (2015): 64.

 Paolo Castiglioni, et al.,

“Multiscale Sample Entropy of cardiovascular signals: Does the choice between fixed-or varying-tolerance among scales influence its evaluation and interpretation?.” Entropy 19.11 (2017): 590.

 Tuan D Pham,

“Time-shift multiscale entropy analysis of physiological signals.” Entropy 19.6 (2017): 257.

 Hamed Azami and Javier Escudero,

“Coarse-graining approaches in univariate multiscale sample and dispersion entropy.” Entropy 20.2 (2018): 138.

`cMSEn`(Sig, Mobj, varargin)

cMSEn returns the composite multiscale entropy of a univariate data sequence.

[MSx, CI] = cMSEn(Sig, Mobj)

Returns a vector of composite multiscale entropy values (`MSx`) for the data sequence (`Sig`) using the parameters specified by the multiscale object (`Mobj`) using the composite multiscale entropy method (cMSE) over 3 temporal scales.

[MSx, CI] = cMSEn(Sig, Mobj, name, value, …)

Returns a vector of composite multiscale entropy values (`MSx`) for the data sequence (`Sig`) using the parameters specified by the multiscale object (`Mobj`) and the following name/value pair arguments:

• `Scales` - Number of temporal scales, an integer > 1 (default: 3)

• `RadNew` - Radius rescaling method, an integer in the range [1 4]. When the entropy specified by `Mobj` is `SampEn` or `ApEn`, RadNew rescales the radius threshold in each sub-sequence at each time scale (Xt). If a radius value (`r`) is specified by `Mobj`, this becomes the rescaling coefficient, otherwise it is set to 0.2 (default). The value of `RadNew` specifies one of the following methods:

•  Standard Deviation - r*std(Xt)

•  Variance - r*var(Xt)

•  Mean Absolute Deviation - r*mad(Xt)

•  Median Absolute Deviation - r*mad(Xt,1)

• `Refined` - Refined-composite MSEn method. When `Refined == true` and the entropy function specified by `Mobj` is `SampEn`, `cMSEn` returns the refined-composite multiscale entropy (rcMSEn). (default: false)

• `Plotx` - When `Plotx == true`, returns a plot of the entropy value at each time scale (i.e. the multiscale entropy curve) (default: false)

MSobject, MSEn, rMSEn, hMSEn, XMSEn, cXMSEn, SampEn, ApEn,

References:
 Madalena Costa, Ary Goldberger, and C-K. Peng,

“Multiscale entropy analysis of complex physiologic time series.” Physical review letters 89.6 (2002): 068102.

 Vadim V. Nikulin, and Tom Brismar,

“Comment on “Multiscale entropy analysis of complex physiologic time series”.” Physical review letters 92.8 (2004): 089803.

 Madalena Costa, Ary L. Goldberger, and C-K. Peng.

“Costa, Goldberger, and Peng reply.” Physical Review Letters 92.8 (2004): 089804.

 Shuen-De Wu, et al.,

“Time series analysis using composite multiscale entropy.” Entropy 15.3 (2013): 1069-1084.

 Shuen-De Wu, et al.,

“Analysis of complex time series using refined composite multiscale entropy.” Physics Letters A 378.20 (2014): 1369-1374.

`rMSEn`(Sig, Mobj, varargin)

rMSEn returns the refined multiscale entropy of a univariate data sequence.

[MSx,CI] = rMSEn(Sig, Mobj)

Returns a vector of refined multiscale entropy values (`MSx`) and the complexity index (`CI`) of the data sequence (`Sig`) using the parameters specified by the multiscale object (`Mobj`) and the following default parameters: `Scales` = 3, Butterworth LPF Order = 6, Butterworth LPF cutoff frequency at scale (T): Fc = 0.5/T. If the entropy function specified by `Mobj` is `SampEn` or `ApEn`, `rMSEn` updates the threshold radius of the data sequence (Xt) at each scale to 0.2*std(Xt) when no `r` value is provided by `Mobj`, or r*std(Xt) if `r` is specified.

[MSx,CI] = rMSEn(Sig, Mobj, name, value, …)

Returns a vector of refined multiscale entropy values (`MSx`) and the complexity index (`CI`) of the data sequence (`Sig`) using the parameters specified by the multiscale object (`Mobj`) and the following name/value pair arguments:

• `Scales` - Number of temporal scales, an integer > 1 (default: 3)

• `F_Order` - Butterworth low-pass filter order, a positive integer (default: 6)

• `F_Num` - Numerator of Butterworth low-pass filter cutoff frequency, a scalar value in range [0 < `F_Num` < 1]. The cutoff frequency at each scale (T) becomes: Fc = `F_Num`/T. (default: 0.5)

• `RadNew` - Radius rescaling method, an integer in the range [1 4]. When the entropy specified by `Mobj` is `SampEn` or `ApEn`, RadNew rescales the radius threshold in each sub-sequence at each time scale (Xt). If a radius value (`r`) is specified by `Mobj`, this becomes the rescaling coefficient, otherwise it is set to 0.2 (default). The value of `RadNew` specifies one of the following methods:

•  Standard Deviation - r*std(Xt)

•  Variance - r*var(Xt)

•  Mean Absolute Deviation - r*mad(Xt)

•  Median Absolute Deviation - r*mad(Xt,1)

• `Plotx` - When `Plotx == true`, returns a plot of the entropy value at each time scale (i.e. the multiscale entropy curve) [default: false]

MSobject, MSEn, cMSEn, hMSEn, XMSEn, rXMSEn, SampEn, ApEn

References:
 Madalena Costa, Ary Goldberger, and C-K. Peng,

“Multiscale entropy analysis of complex physiologic time series.” Physical review letters 89.6 (2002): 068102.

 Vadim V. Nikulin, and Tom Brismar,

“Comment on “Multiscale entropy analysis of complex physiologic time series”.” Physical review letters 92.8 (2004): 089803.

 Madalena Costa, Ary L. Goldberger, and C-K. Peng.

“Costa, Goldberger, and Peng reply.” Physical Review Letters 92.8 (2004): 089804.

 José Fernando Valencia, et al.,

“Refined multiscale entropy: Application to 24-h holter recordings of heart period variability in healthy and aortic stenosis subjects.” IEEE Transactions on Biomedical Engineering 56.9 (2009): 2202-2213.

 Puneeta Marwaha and Ramesh Kumar Sunkaria,

“Optimal selection of threshold value ‘r’for refined multiscale entropy.” Cardiovascular engineering and technology 6.4 (2015): 557-576.

`hMSEn`(Sig, Mobj, varargin)

hMSEn returns the hierarchical entropy of a univariate data sequence.

[MSx,Sn,CI] = hMSEn(Sig, Mobj)

Returns a vector of entropy values (`MSx`) calculated at each node in the hierarchical tree, the average entropy value across all nodes at each scale (`Sn`), and the complexity index (`CI`) of the hierarchical tree (i.e. `sum(Sn)`) for the data sequence (`Sig`) using the parameters specified by the multiscale object (`Mobj`) over 3 temporal scales (default). The entropy values in `MSx` are ordered from the root node (S_00) to the Nth subnode at scale T (S_TN): i.e. S_00, S_10, S_11, S_20, S_21, S_22, S_23, S_30, S_31, S_32, S_33, S_34, S_35, S_36, S_37, S_40, … , S_TN. The average entropy values in `Sn` are ordered in the same way, with the value of the root node given first: i.e. S0, S1, S2, …, ST

[MSx,Sn,CI] = hMSEn(Sig, Mobj, name, value, …)

Returns a vector of entropy values (`MSx`) calculated at each node in the hierarchical tree, the average entropy value across all nodes at each scale (`Sn`), and the complexity index (`CI`) of the entire hierarchical tree for the data sequence (`Sig`) using the following name/value pair arguments:

• `Scales` - Number of temporal scales, an integer > 1 (default = 3) At each scale (T), entropy is estimated for 2^(T-1) nodes.

• `RadNew` - Radius rescaling method, an integer in the range [1 4]. When the entropy specified by `Mobj` is `SampEn` or `ApEn`, RadNew rescales the radius threshold in each sub-sequence at each time scale (Xt). If a radius value (`r`) is specified by `Mobj`, this becomes the rescaling coefficient, otherwise it is set to 0.2 (default). The value of `RadNew` specifies one of the following methods:

•  Standard Deviation - r*std(Xt)

•  Variance - r*var(Xt)

•  Mean Absolute Deviation - r*mad(Xt)

•  Median Absolute Deviation - r*mad(Xt,1)

• `Plotx` - When `Plotx == true`, returns a plot of the average entropy value at each time scale (i.e. the multiscale entropy curve) and a hierarchical graph showing the entropy value of each node in the hierarchical tree decomposition. (default: false)